Articles

Plain explanations of what these assessments measure, written for the person having them and for the clinician reading the report.

  • Does Obesity Cause Cancer? What Your Metabolic Numbers Add

    Does Obesity Cause Cancer? What Your Metabolic Numbers Add Yes, for a growing list of cancers: higher BMI is tied to greater risk of 19 cancer types, and the risk travels through what excess fat does to blood sugar, insulin and inflammation. About four in ten US cancers trace to factors people can change, and…

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  • Nutrition Before Surgery: What to Have Measured While You Wait

    Nutrition Before Surgery: What to Have Measured While You Wait Nutrition before surgery shapes how you heal: malnourished spine surgery patients had 2.10 times the odds of wound complications and 2.77 times the odds of sepsis. The standard preoperative workup checks your heart and lungs for anesthesia, not the materials you need to heal. An…

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  • Malnutrition in Obesity: Screening the Patient a BMI Hides

    Malnutrition in Obesity: Screening the Patient a BMI Hides Malnutrition in obesity is diagnosed at any BMI under the GLIM criteria, for example reduced muscle mass plus inflammation. The usual screens miss it: among older outpatients with a BMI of 25 or more, 58.8% of those malnourished passed the short-form screen. A patient can carry…

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  • Remitted Depression and Cognitive Decline: A Screening Trigger

    Remitted Depression and Cognitive Decline: A Screening Trigger Remitted depression is a screening trigger for cognitive decline: in one cohort of older adults whose depression had lifted, about one in four developed dementia within five years. That history is a reason to set a standardized cognitive baseline and follow it. Remission ends the mood episode,…

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  • Body Fat Distribution and Dementia Risk: Screening Beyond the Scale

    Body Fat Distribution and Dementia Risk: Screening Beyond the Scale Body fat distribution shifts dementia risk: among 412,691 UK Biobank adults, a central fat pattern and fat concentrated in the arms each predicted more neurodegenerative disease, and muscle strength predicted less. Where fat sits and how much muscle surrounds it predicted neurodegenerative disease in a…

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  • Modifiable Risk Factors for Dementia: What Primary Care Can Measure

    Modifiable Risk Factors for Dementia: What Primary Care Can Measure Primary care can measure four of the 14 modifiable dementia risk factors in the 2024 Lancet Commission with a number: blood pressure, glucose regulation, LDL cholesterol and adiposity. The others have to be asked about, and some were settled long before the visit. A population…

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  • Ketones as Brain Fuel: The Entrance Insulin Resistance Cannot Close

    Ketones as Brain Fuel: The Entrance Insulin Resistance Cannot Close Ketones fuel the brain without insulin: they enter nerve cells through carriers that depend on neither insulin nor the GLUT4 glucose transporter. When insulin resistance closes part of the glucose supply to the memory circuits, ketones still get in. The memory circuits partly depend on…

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  • Brain Insulin Resistance in Alzheimer Disease: Why Type 3 Diabetes

    Brain Insulin Resistance in Alzheimer Disease: Why Type 3 Diabetes Brain insulin resistance in Alzheimer disease means the brain both makes less insulin and stops answering it, a pattern found in donated brain tissue even from people without diabetes. That is why the disease was named type 3 diabetes. The label came from pathologists holding…

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  • Gut Bacteria, Stress and the Clock Your Body Runs On

    Gut Bacteria, Stress and the Clock Your Body Runs On Gut bacteria help set the daily rhythm of your stress response, which runs highest around waking and lowest at night. In mice, removing gut bacteria left the stress hormone released at the wrong times of day, not in the wrong amount. The same bad news…

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  • Metabolic Osteoarthritis: Screening the Hand and Younger Joint

    Metabolic Osteoarthritis: Screening the Hand and Younger Joint Metabolic osteoarthritis screening belongs in two presentations: osteoarthritis in the finger joints, which carry almost no load, and osteoarthritis that starts unexpectedly young. In both, a glycemic, insulin and lipid panel is the right first test. Load explains the knee. It does not explain the interphalangeal joint,…

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